BENY LAFER
Professor Assistente Doutor do Departamento de Psiquiatria da FMUSP. Coordenador do Projeto de Assistência e Pesquisa em Transtorno Bipolar (PROMAN) do Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (IPq-HC-FMUSP).
MARCIA BRITTO DE MACEDO SOARES
Mestre em Medicina pela FMUSP. Médica psiquiatra colaboradora do PROMAN-IPq-HC-FMUSP.
Abstract:
The treatment of bipolar depression has been an area of debate. The use of antidepressants, particularly the triciclics, has been associated with worse clinical outcomes. Evidence points to a limited efficacy of traditional mood stabilizers such as lithium, valproate and carbamazepine in the treatment of bipolar depression. In cases where depression is more severe, there is evidence that antidepressants may be useful. The use of antidepressants should be in association with a mood stabilizer. New agents such as lamotrigine have been put forward as effective in the treatment of bipolar depression. Recent studies using lamotrigine suggest its efficacy and safety in the treatment of bipolar depression.
Keywords:Bipolar depression, treatment, antidepressants.