Patients who have major depression with psychotic features have greater morbidity and mortality than patients with non-psychotic major depression. Despite the frequent relapse and recurrence in major depression with psychotic features, there are few studies of the efficacy and maintenance treatments. The purpose of this study is to determine the best way to treat psychotic depression after remission of symptoms. After a Systematic Bibliography review three studies were found and only one met all pre-established sets of criteria. Psychotic depression is a severe form of Mood Disorder and the use of antipsychotics during maintenance and continuation phase is poorly tested and there aren’t conclusive results. Two cases are presented.