I read with interest a very comprehensive article titled “Antioxidant effect of buspirone in epilepsy model induced by pilocarpine” by Ferreira et al. published in the December issue of Revista de Psiquiatria Clínica. In brief, the authors demonstrated that the pretreatment with buspirone has an anticonvulsant and antioxidant effect during the acute period of pilocarpine model of temporal lobe epilepsy. Given the dearth of published data about the relation of buspirone and epilepsy, we applaud Dr. Ferreira et al. for pursuing this topic, but I also find it necessary to address some purposes regarding their comments. Initially developed for use in the treatment of generalised anxiety disorder, it appears that buspirone may be useful in various other psychiatric and neurological disorders, such as attenuating side effects of Parkinson’s disease therapy, ataxia, depression, social phobia, and behaviour disturbances following brain injury, and those accompanying Alzheimer’s disease, dementia and attention deficit disorder.