Background: Women undergoing assisted reproduction with antagonist protocols face challenges related to psychological stability and quality of life. Solution-Focused Brief Therapy (SFBT) is a therapeutic approach that focuses on problem-solving and resource utilization, while family collaborative care intervention emphasizes the involvement and support of family members. However, there is limited research on the effects of combining SFBT with family collaborative care intervention on the psychological stability and quality of life of women undergoing assisted reproduction with antagonist protocols. Objective: This study aims to investigate the impact of combining SFBT with family collaborative care intervention on the psychological stability and quality of life of women undergoing assisted reproduction with antagonist protocols, and provide a theoretical foundation and data support. Methods: A randomized controlled trial design was employed in this study. A total of 100 women meeting the criteria for assisted reproduction with antagonist protocols, aged between 25 and 40, were recruited. Participants were randomly assigned to either the experimental group or the control group, with 50 participants in each group. The experimental group received a 12-week intervention combining SFBT and family collaborative care, while the control group received standard care. Psychological assessments and quality of life measurements were conducted using the following instruments before and after the intervention:1, Psychological stability measurement: The Hamilton Anxiety Scale and the Hamilton Depression Scale were used to assess the severity of anxiety and depression symptoms. Total scores were calculated, with lower scores indicating better psychological stability.2, Quality of life measurement: The Quality of Life Questionnaire was utilized to assess participants' quality of life. The questionnaire includes multiple dimensions such as physical health, social support, and emotional well-being, with scores ranging from 0 to 100. Higher scores indicate better quality of life. Results: At the end of the intervention, the experimental group demonstrated significantly higher scores in psychological stability compared to the control group (mean score in the experimental group: 18.6, mean score in the control group: 25.2, p < 0.001). Additionally, the experimental group showed significantly higher total scores and scores in each dimension of quality of life compared to the control group (p < 0.001), including physical health (mean score in the experimental group: 80.3, mean score in the control group: 62.8), social support (mean score in the experimental group: 76.9, mean score in the control group: 58.4), and emotional well-being (mean score in the experimental group: 82.5, mean score in the control group: 65.2). Conclusion: The results of this study suggest that combining SFBT with family collaborative care intervention has a significant positive impact on the psychological stability and quality of life of women undergoing assisted reproduction with antagonist protocols. These findings provide a theoretical foundation and data support for clinical practice, offering feasible strategies to improve patient care.