Objective To study the efficacy and safety of glass fiber post combined with nano-composite resin on permanent anterior teeth trauma in children, so as to give a certain basis for the therapy of children with permanent anterior teeth trauma in clinic and improve the prognosis of children. Methods A retrospective analysis was performed on 153 children with permanent anterior teeth trauma who were examined and treated in our hospital May 2021 to March 2023. Based on the random number table method, children were divided into a glass fiber post group, a nano-composite resin group, and a glass fiber post combined with nano-composite resin group (joint group), and were treated with glass fiber post, nano-composite resin, and glass fiber post combined with nano-composite resin, respectively. The efficacy, shedding of restoration materials, pain degree, and the impact of periodontal condition of children were analyzed, and the frequency of adverse reactions and treatment satisfaction of kids in the 3 groups were observed. Results In comparison of the glass fiber post one and the nano-composite resin one, the effective ratio of the joint one was obviously increased ( P <0.05). In comparison of the glass fiber post one and the nano-composite resin one, the shedding ratio of restoration materials in the joint one was obviously reduced ( P <0.05). One week after treatment and three months after treatment, compared with the glass fiber post one and the nano-composite resin one, the pain degree in the joint one was obviously decreased ( P <0.05). In comparison of the glass fiber post one and the nano-composite resin one, the gingival index, gingival sulcus bleeding index and tooth looseness in the joint one were obviously decreased ( P <0.05). In comparison of the glass fiber post one and the nano-composite resin one, the frequency of adverse reactions in the joint one was obliviously decreased ( P <0.05). In comparison of the glass fiber post one and the nano-composite resin one, the children in the combination group had significantly higher scores on appearance, comfort, chewing, speech and fixation ( P <0.05). However, it had no obvious distinction in each index between the glass fiber post one and the nano-composite resin one ( P >0.05). Conclusion Glass fiber post combined with nano-composite resin is an effective treatment method, which can effectively reduce the shedding of restoration materials, reduce pain, improve periodontal conditions, and improve nursing satisfaction. It is safe and worthy of clinical application and promotion.