Objective: To investigate the impact of a propofol and remifentanil anesthetic regimen on patients undergoing gastroscopy who experience psychological anxiety. Methods: The subjects of this study were 166 people who had a gastroscopy at our institution between January and December of 2021. These people were randomly assigned to one of two groups, the control group or observation group, with 83 people in each. Propofol and saline were used to induce sleep for the control group, whereas propofol and remifentanil were used for the observation group prior to gastroscopy. The incidence of adverse responses, the anesthesia index, the vital sign index, and the psychological condition were all noted. Results: Comparison of the propofol dose, the time of anesthetic onset, the time of eye opening, and the time of discharge from the hospital between the observation group and the control group revealed statistically significant differences (P<0.05). Both groups' HR, SpO2, and MAP levels at T1 were considerably lower than those at T2 and T3, with the observation group's HR, SpO2, and MAP levels at all three time points being lower than the control group's (P<0.05). The post-examination scores for both groups decreased in terms of psychological anxiety and increased in terms of comfort compared to the pre-examination levels. For psychological anxiety, the observation group scored substantially lower than the control group (P<0.05), whereas the comfort score increased much more than the control group. The rate of agitation was 0% in the observation group, whereas it was 2.41 % in the control group. The rate of nausea and vomiting was 3.61 % higher in the observation group, while it was 1.20 % higher in the control group (P<0.05). Conclusion: Propofol mixed with remifentanil is a promising anesthetic regimen for patients having gastroscopy, since it can stabilize vital signs, reduce psychological worry, and speed up recovery time, but it also increases anesthesia discomfort and needs more research.