Objective: Studying the effectiveness and safety of combining acupuncture with standard medications for the treatment of ischemic optic neuropathy (ION). Methods: Seventy patients with ION were admitted to our hospital between February 2021 and May 2022, and their clinical records were reviewed retrospectively. They were split up into two groups, one receiving conventional drug therapy (n=35) and the other receiving acupuncture in addition to conventional drug treatment (n=35). Both groups of patients were compared for their therapeutic outcomes and their TCM symptom scores. Blood samples were taken from patients in both groups while they were fasting, and a hemorheology analyzer was used to determine the low-shear and high-shear viscosities of the entire blood. The fibrinogen (Fg) concentration was measured with an automated coagulation analyzer. Electrophysiological indicators [Pattern visual evoked potentials (PVEP) amplitude, PVEP latency value], morphological indicators [overall mean retinal nerve fiber layer (RNFL) thickness, overall mean macular ganglion cell complex (GCC) thickness], and the levels of visual function [best corrected visual acuity (BCVA), mean sensitivity (MS), mean defect (MD), loss of variance (LV)] were detected before and after treatment. Patients were tracked to see how often they experienced adverse responses, and the two groups were compared. Results: Total patient effectiveness in the control group was 77.14%, whereas the effectiveness rate in the observation group was 94.29%. There was a statistically significant difference between the two groups, with the observation group having a higher overall effective rate (P<0.05). When patients in both groups were assessed again after therapy, they showed considerable improvements in their BCVA, MD, MS, and LV. Patients in the observation group had considerably worse BCVA, MD, and LV than those in the control group (P< 0.05), and significantly greater MS than those in the control group (P<  0.05). The PVEP amplitude and PVEP potential value of patients in both groups considerably increased after treatment, with the PVEP amplitude and PVEP potential value of patients in the observation group being significantly lower than those in the control group (P<0.05). While both groups had significant increases in RNFL and GCC post-treatment, the observation group saw a larger increase in RNFL and a smaller decrease in GCC than the control group (P<0.05). Patients in both groups saw notable improvements in their low-shear blood viscosity, high-shear blood viscosity, and Fg after treatment, with the observation group seeing significantly lower levels of all three variables compared to the control group (P<0.05). After receiving therapy, patients in both groups showed considerable improvements in their TCM syndrome scores, albeit those in the observation group had a higher baseline score than those in the control group (P<  0.05). Patients in the control group experienced fewer adverse events than those in the observation group, at 8.57 percent. Patients in both groups experienced similar rates of adverse responses, with no discernible difference between them (P>0.05). Conclusion: When acupuncture is coupled with medicine to treat ION, therapeutic advantages, blood perfusion, Traditional Chinese Medicine (TCM) symptoms of ION, visual function, and optic nerve damage are all strengthened. In addition to being somewhat secure, this method has the potential for extensive use.