There is a close relationship between the level of nursing in the emergency department and the hospital's ability to cope with sudden accidents. Emergency nursing not only requires the hospital to have perfect and advanced hardware equipment, but also requires the nursing staff to have excellent nursing ability, high nursing service awareness and rich knowledge reserve. The nursing level of emergency department can directly reflect the nursing quality of the hospital. Evidence-based nursing is one of the commonly used nursing modes in emergency department and clinical departments, and it is also an indispensable new nursing mode in emergency department. The clinical application of evidence-based nursing in neurosurgery, general surgery, internal medicine and other emergency departments has been analyzed and summarized in recent years. It is believed that the application value of this nursing model is higher, and has a broad application prospect, which has the value of in-depth study and further promotion.