Objective: To survey the effects of interventional embolization combined with psychological and behavioral interventions on anxiety and depression and prognosis in patients with cerebral aneurysms. Methods: During February 2019 to April 2022, 100 patients with cerebral aneurysms cured in our hospital were enrolled for the study. All patients were arbitrarily classified into control group (n=50) and study group (n=50). The former accepted interventional embolization combined with routine nursing intervention, and the latter accepted interventional embolization therapy, and psychological and behavioral interventions. Nursing satisfaction, anxiety and depression score, heart rate (HR), mean arterial pressure (MAP), incidence of complications, self-management ability score and quality of life score were compared. Results: In the study group, 30 cases were very pleased, 11 cases were full, and 9 cases were fair, and the satisfaction rate was 100.00%; in the control group, 20 cases were very pleased, 12 cases were satisfactory, 9 cases were fair, and 9 cases were unsatisfactory. The nursing satisfaction of the research group was higher. After nursing interventions, the anxiety and depression scores lessened. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of the study group were lower. HR and MAP in the study group were lower, and the fluctuation range was smaller. The incidence of complications such as postoperative rebleeding, headache, hematoma at the puncture site, and dizziness in the study group was lower. Both groups' self-management ability scores improved after treatment. At discharge, one month, three months, and six months after discharge, the study group had higher self-management ability scores. The scores for physical functioning, psychological functioning, social functioning and health self-perception were lower in the study group. Conclusion: Psychological and behavioral interventions for patients with cerebral aneurysms can be effective in improving their anxiety and depression and reducing the incidence of complications. Patients who have a correct understanding of the disease and are cooperative can also improve their life quality. The intervention has been well received by patients and is worthy of further investigation and dissemination.