Following the DSM-5 a drug-induced psychotic disorder (DIPD) occurs when there is clear evidence that the psychotic disorder is causally linked to the intake of a psychosis-inducing medication. Symptoms of psychosis occur quickly after drug-intake and disappear, once the medication is metabolized. DIPD have a good prognosis and do not require a long-term treatment with antipsychotics. A 47 years old woman, married and illiterate from Eslamabad-e Gharb City (Iran), complained about severe restlessness, irritability and mood swings in pre- and post-menstruation cycles. She was referred to the hospital, where low doses of an SSRI and a benzodiazepine were administered. During the first five days of hospitalization, no signs of psychosis (delusion, hallucination, disturbance in reality testing or formal thought disorders) were observed. Further, to exclude gynecological issues related to severe pre- and post-menstrual syndromes, the patient underwent ultrasonography of the uterus and ovaries, where simple bilateral ovarian cysts were observed, which, however, were very unlikely to be causally associated to severe pre- and post-menstrual syndromes. Next, Vitex agnus castus (VAC, Femodin^®; chasteberry) was prescribed (20 mg/d in tablets). VAC is the only evidence-based herbal medication for pre-menstrual syndromes. Further, Cerqueira et al. described its efficacy in their systematic review, while Verkaik et al. were more critical in their meta-analysis and systematic review. 24h after VAC intake, the patient clearly showed formal thought disorders, auditory and visual hallucinations, disturbances in reality testing, disorganized behavior and speech; negative symptoms were not observed. Administration of VAC was discontinued, and within 48h symptoms of psychosis fully disappeared.