Zeyang Yao
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Luyin Liu
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Jiaxin Li
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Yifan Liu
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Guining Liang
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Wanshu Du
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Jiale Tong
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Yili Wang
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Yuxiang Ma
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Xingchi Du
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Shanshan Chen
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Mengxin Gao
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Baoxia Li
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Fen Zhou
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Yan Liu
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Shengqiang Chen*
The Third Clinical University, Guangzhou Medical University, Guangzhou 511495, Guangdong
Abstract:
Objective To explore whether an enriched environment can improve depression-like behavior in chronic restraint stress mice of depression. Methods Thirty healthy female and male C57/6J mice aged 7-8 weeks were divided into 4 groups according to the experimental purpose: Model group(After 21 days of chronic restraint, saline water was injected for 21 days), Fluoxetine group(After 21 days of chronic restraint, Fluoxetine was injected for 21 days), Enriched environment group( After 21 days of chronic restraint, the rearing cage-enriched environment was cultured for 21 days), matched group ( After 21 days of normal culture, the rearing cage-enriched environment was cultured for 21 days). The depression - like behavior of mice was evaluated by the sucrose preference test and the elevated plus maze test. Results 1.Mice in the fluoxetine group, enriched environment group and matched group had significantly higher sugar water preference rates than in the model group（P<0.05）, moreover, the differences between the fluoxetine group, the enriched environment group and the control group were not significant (P> 0.05). 2.Mice in the fluoxetine group, enriched environment group and matched group had a significantly higher proportion of open arm time(OT%) than in the model group（P<0.05）, moreover, the differences between the fluoxetine group, the enriched environment group and the control group were not significant (P> 0.05). Conclusion The enriched environment improved depression - like behavior in chronic restraint stress mice of depression.
Keywords:Depression; Chronic restraint stress; Enriched environment; The elevated plus maze (EPM); Sugar water preference; Fluoxetine