Objective: To investigate the clinical value of intensive care in patients with myocardial injury combined with septic shock (SS) using pulse index continuous cardial output (PICCO). Methods: Seventy-two patients with myocardial injury combined with SS who were treated in our ICU between October 2020 and October 2022 were collected for this study, patients who received intensive care interventions were the observation group (n=40) and those who received conventional nursing interventions were the control group (n=32). The time of ICU monitoring, PICCO monitor use and hospitalization were recorded for both groups. Patients’ psychology was assessed by the self-rating anxiety scale (SAS) and self-rating depression scale (SDS), and the self-perception was evaluated by the subjective self-rated scale of well-being (SWB), and the VAS pain rating scale was used to assess the pain in both groups. The satisfaction and adverse reactions of patients in both groups to the nursing strategy were also investigated. Finally, the GQOL-74 scale was used to assess the quality of life of patients in both groups. Results: The time of ICU monitoring, PICCO monitor use, and hospitalization were shorter in the observation group than in the control group (P<0.05), and the SAS, SDS, and VAS after nursing were lower than in the control group, while the SWB was higher than in the control group (P<0.05). In addition, nursing satisfaction was higher in the observation group compared with the control group, and the incidence of adverse reactions was lower (P<0.05). Moreover, the GQOL-74 scores were also higher in the observation group than in the control group (P<0.05). Conclusion: Intensive care can effectively improve the negative psychology and physical pain of patients with myocardial injury combined with SS using PICCO monitors, and improve the treatment effect, which has high clinical application value.