The translation ability is the basis for developing the hearing and composition of the composition. However, the English translation education of the university is the most neglected content in the English language education of the University, and there are many problems which decrease the quality of the English translation education of the University. In order to improve the present state of English translation education of universities, it is necessary to cultivate students' intercultural exchange awareness and ability as an emphasis on translation education. Therefore, the translation education really aimed at the student to overcome the difference between the foreign countries culture and to make the communication disorder zero. English translation education of higher education institutions mainly cultivates students' English and cultural exchange skills, and reflects the nature of cross-cultural education. The difference of culture is always difficult to overcome when learning English translation. We analyzed the intercultural communication skills in the English translation education from the angle of difference in culture. Cultural differences are obstacles and challenges in teaching English translation, and understanding the differences between the two cultures makes it more smooth and accurate to change between bilingual. Different historical cultures, territorial culture, traditional culture, ideas, religious beliefs, and psychological associations can lead to cultural differences. With the development of the pluralization of the world, the interchange between countries becomes more and more close, and it is important to develop international trade and science. English study is an important part. English translation education is a basic prerequisite to increase the level of English in the whole country. The purpose of this research is to clarify the importance of focusing on students' intercultural exchange awareness in English translation education.