Objective: Based on the existing clinical trials, a meta-analysis  was  conducted  on  the  efficacy  of  acupuncture  and  moxibustion  combined  with acupressure in the treatment of CINV and the patients' stigma and quality of life, so as to provide reference for clinical practice.Methods:In this study, PubMed, PMC, CNKI and other databases were searched to find randomized controlled trials (RCTS) of acupuncture combined with acupressure in the treatment of CINV and its effect on patients' stigma and quality of life. Then, according to the title, abstract and key words, appropriate literatures were selected for inclusion. The Cochrane risk bias assessment tool was used to evaluate the quality of the included studies. RevMan5.4.1 software was used to conduct a meta-analysis of the important indicators in the literature through the quality assessment.Results:  A  total  of  342  articles  were  selected  according  to  keywords,  including  22  repeated  articles.  Non-clinical  trials  were  excluded, leaving 70 articles. Excluding articles with inconsistent detection indicators and incomplete content, a total of 25 articles that could be read were obtained. According to the specific content of the literature, 14 articles with high quality were selected for Meta-analysis. The meta results showed that acupuncture combined with acupressure could effectively prevent the occurrence of CINV, and the effective rate was high [95%CI (15.99, 28.44), P<0.00001]. Compared with conventional treatment, patients are more inclined to acupuncture-moxibustion combined with acupressure treatment [95%CI (16.60, 33.89), P<0.00001], which can effectively improve QOL [95%CI (1.84, 13.14), P=0.009] of patients and reduce the side effects of chemotherapy such as constipation [95%CI (-11.76, -6.36), P<0.00001] and insomnia [95%CI (-21.31, -1.89), P=0.02].Conclusion: Acupuncture and moxibustion combined with acupressure can effectively relieve CINV, significantly reduce the stigma  of  patients,  and  improve  the  quality  of  life  of  patients.  Therefore,  acupuncture  and  moxibustion  combined  with  acupressure  is  expected to become an effective treatment for CINV.