Objective: At present, there are various methods for the treatment of cervical intraepithelial neoplasia (CIN), among which loop electrosurgical excision procedure (LEEP) is a relatively effective treatment. In order to let the public better understand and recognize the application of this technology in cervical lesions, the existing relevant literature was summarized and analyzed, and the efficacy of loop electrosurgical excision in the treatment of cervical epithelial neoplasia was further described. Methods: The Embase database was searched for randomized controlled trials (RCTS) on the efficacy of LEEP in the treatment of CIN. Then, the literature was initially screened based on the abstracts. According to the specific experimental content of the literature, the appropriate literature was selected for inclusion and analysis. The Cochrane risk bias assessment tool was used to evaluate the quality of the included studies. RevMan5.4.1 software was used to conduct a meta-analysis of the important indicators of the literature that passed the quality assessment. Results: A total of 12 articles with relatively complete data and small bias were included for Meta-analysis. This meta-analysis included 1385 patients in the experimental group and 1432 patients in the control group. The results showed that the recurrence rate of CIN patients treated with LEEP was lower [95%CI (-25.08, -10.88), P<0.00001], the effective rate was higher [95%CI (11.97, 33.98), P<0.0001], and the patients' depression was significantly relieved [95%CI (-37.39, -6.37), P=0.006]. Conclusion: LEEP is effective and safe in the treatment of CIN, which can not only reduce the incidence of cervical cancer, but also reduce the depression of patients, which is worthy of further clinical application.