Objectives: To observe the clinical efficacy of acupuncture and moxibustion combined with low-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of early intervention in the treatment of post-stroke patients with aphasia. Methods: From October 2019 to October 2020, 60 patients with post-stroke perispasial aphasia in outpatient and hospitalization of our hospital were selected and randomly divided into observation group and control group, with 30 cases in each group. The control group was treated with a conventional treatment plan, and the observation group was treated with a conventional treatment plan + acupuncture + repeated transcranial magnetic stimulation. The ABC score and MMSE score were performed on the two groups of patients at 2 weeks, 2 months, 4 months, and 6 months after the course of treatment to determine the treatment effect. Results: The general information of the two groups of patients was compared, and it was found that the two groups of patients had no significant statistical differences in gender and type of aphasia (P>0.05), which was comparable. After comparing the two groups of patients before and after treatment, it was found that there was no significant statistical difference between the two groups before treatment (P<0.05). After treatment, the ABC score of the experimental group increased significantly, and the difference between the two groups was significant (P <0.05). After comparing the MMSE scores of the two groups of patients, it was found that the scores of the two groups of patients improved after treatment, but compared with the control group, the scores of the observation group increased more significantly. Starting from 2 weeks after the course of treatment, patients in the observation group The score of is significantly higher than that of the control group, and the difference between the two groups is statistically significant (P<0.05). Subsequently, we compared the occurrence of adverse reactions between the two groups of patients, and the results showed that there was no significant statistical difference in the occurrence of adverse reactions between the two groups of patients (P<0.05). Conclusions: Acupuncture combined with low-frequency transcranial magnetic stimulation has a certain rehabilitation effect on the language function of patients with post-stroke perispasm aphasia, and is relatively safe. The mechanism may be related to the increase of local blood flow in the language area and improvement of brain metabolism through the remote effect. , It is related to inhibiting the excitability of the response area of ​​the right hemisphere.