Gao Xiaofeng
Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, China.
Ni Yanfei
Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, China.
Deng Mengling
Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, China.
Chen Yunyu
Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, China.
Yao Juan
Psychiatry nursing, The Third Hospital of Quzhou, Quzhou 324000, China.
He Xianyan
Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, China
Abstract:
Objective: To investigate the role of high-throughput sequencing in the study of gut microbiota variety in schizophrenia patients. Methods: 60 participants were used for this study with 40 patients with schizophrenia selected for the Illness group which further divided into 20 acute phase patients and 20 remission patients. The remaining 20 were in the Control group. Fecal bacterial composition of study subjects was analysed and compared using PANSS among the test groups for relative abundance. Results: A significant difference between the acute and remission groups was found in the PANSS scores and the sum of all components (P<0.05). Compared to the remission group, the acute group had a higher abundance of and lower abundance. Conclusion: During the onset and remission stages of schizophrenia, there are significant variations in the structure and variety of the intestinal flora. This indicates a potential correlation between disease control and intestinal flora structure.
Keywords:Schizophrenia, High-throughput sequencing, Intestinal flora