Patients with diabetes face a serious health risk, making it among the most significant disease problems of the 21st century. Patients mostly have a mental disorder, which makes treatment more challenging and increases the risk of relapse. In this study, 121 Type-2 Diabetes (T2D) patients were divided into two groups and treated for two months. The experimental group got normal care, whereas the control group received Health Education (HE) that was based on “Protection Motivation Theory (PMT)”. Before the therapy, there is no variation among the control and experimental groups that are significant (P>0.05). However, following the post-treatment, the experimental group's blood glucose level and level of depression were substantially lower than those of the control group (P 0.05), although their levels of stigma and Quality of Life (QOL) were significantly higher. After the treatment, the experimental group's levels of blood sugar and depression scale get down (P<0.05), while their QOL and stigma go up dramatically (P<0.05). The blood sugar levels, depression, stigma, and QOL of the control group are not different prior to and after the treatment (P>0.05). The integration of HE and PMT is crucial for lessening the stigma associated with T2D patients, enhancing their QOL, and lowering their blood sugar levels. Analyses of Variance (ANOVA) are the statistical tools of choice for this investigation, which is used to analyze our research methodology.