Effect of recurrent TMS and psychological therapy on Parkinson's patients' cognitive performance, anxiety, and depressed mood

Abstract

Objective: To look at the effects of cognitive function, anxiety, and depression on Parkinson's patients who receive psychosocial therapy along with repetitive transcranial magnetic stimulation (rTMS). Methods: Between January 2020 and January 2022, our hospital took in a total of 100 Parkinson's disease patients, of which 50 were randomly divided into an observational control group and an experimental group using a number table. The experimental group employed a high-frequency (10Hz) rTMS combined psychological intervention treatment mode, while the control group used a low-frequency (0.5Hz) pseudo-rTMS combined psychological intervention treatment mode. The Hamilton Depression Scale (HAMD) and the Hamilton Anxiety Scale (HAMA) were used to evaluate emotional state, the Mini-Mental State Examination (MMSE) was administered to evaluate cognitive function, and the European Research Quality of Life Core Questionnaire was administered to evaluate quality of life in order to make comparisons between treatment modalities and associated clinical conditions (EORTC QLQ-C30). Results: Comparing the experimental and control groups, the combined intervention significantly improved mood, anxiety, and sleep quality in the experimental group (P<0.05); There was no noticeable change (P> 0.05) prior to the therapy. After the combined intervention, the EORTC QLQ-C30 level in relation to the patients' quality of life was considerably higher in the experimental group than in the control group (P<0.05), and the total score in the experimental group was significantly higher than in the control group. Conclusion: Patients with Parkinson's disease benefit from psychological psychotherapy in combination with repeated rTMS, which significantly lowers anxiety and depression while improving quality of life, cognitive performance, and survival confidence.