Sema Inanir
Gaziosmanpasa University, Faculty of Medicine, Department of Psychiatry, Tokat, Turkey.
Serbulent Yigit
Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey.
Feryal Çam Çelikel
Gaziosmanpasa University, Faculty of Medicine, Department of Psychiatry, Tokat, Turkey.
Omer Ates
Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey.
Serap Erdogan Taycan
Gaziosmanpasa University, Faculty of Medicine, Department of Psychiatry, Tokat, Turkey.
Ayse Feyda Nursal
Giresun University, Faculty of Medicine, Department of Medical Genetics, Giresun, Turkey.
Akin Tekcan
Ahi Evran University, School of Health, Kirsehir, Turkey.
Aydın Rustemoglu, Gul Dursun
Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey.
Ahmet Inanir
Gaziosmanpasa University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Tokat, Turkey.
Abstract:
Background: Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in the renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective: The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods: In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results: Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion: Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.
Keywords:Major depressive disorder, angiotensin-converting enzyme, polymorphism.