In the letter by Scorza and Cavalheiro, the authors posit that the use of psychoanalysis for neuropsychiatric syndromes “has a direct positive influence” on neurogenesis. Yet, the authors acknowledge that the putative mechanisms to explain the alleged role of psychoanalysis on neuroplasticity remain “still poorly explored”. In a letter addressed to Wilhelm Fliess in April 1895, Sigmund Freud manifested his willingness to integrate the canons of brain anatomy and physiology with his ideas on psychopathology in order to propose a theoretical model grounded on neurobiological processes.