Thomas Alva Edison, an American inventor, scientist and businessman: If we all did the things we are capable of, we would astound ourselves. Sudden cardiac death (SCD) is the most common lethal manifestation of heart disease, and in many cases it is the descent’s first and only symptom. SCD is defined as “unexpected natural death from a cardiac cause within a short time period, generally ≤ 1 hour from the onset of symptoms, in a person without any prior condition that would appear fatal”. Actually, clinical and pathologic findings suggest that patients with conditions such as coronary artery disease, cardiomyopathy, cardiac rhythm disturbances, or hypertensive heart disease are at high risk of SCD. From epidemiological point of view, the current annual incidence of SCD in the United States (total population approximately 300 000 000) would range between 180 000 and 250 000 cases per year. For the world (total population approximately 6 540 000 000), the estimated annual burden of SCD would be in the range of 4 to 5 million cases per year. Due to this scenario, SCD is considered a major unsolved problem in clinical cardiology, emergency medicine, and public health system.