Mehmet Hamdi Orum
MD. Specialist, Psychiatry, Kahta State Hospital, Adiyaman, Turkey.
Mahmut Bulut
MD. Associate Professor, Department of Psychiatry, Dicle University, Faculty of Medicine, Diyarbakir, Turkey.
Ayse Sevgi Karadag
MD. Assistant Professor, Department of Ophthalmology, Adiyaman University, Faculty of Medicine, Adiyaman, Turkey.
Ebru Dumlupinar
PhD. Researcher, Department of Biostatistics and Medical Informatics, Adiyaman University, Faculty of Medicine, Adiyaman, Turkey.
Aysun Kalenderoglu
MD. Associate Professor, Department of Psychiatry, Adiyaman University, Faculty of Medicine, Adiyaman, Turkey.
Abstract:
Objective: The effect of antipsychotic (AP) drugs on optical coherence tomography (OCT) findings in schizophrenia has not yet been fully elucidated. In this study, we aimed to investigate the effects of APs (the first generation antipsychotic group [FGAG], the second generation antipsychotic group [SGAG], the clozapine group [CG]) on OCT findings in schizophrenia. Methods: The thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroidal thickness were measured using a spectral OCT device. Results: No significant difference was found between FGAG, SGAG, CG (p > 0.05) while there was a significant difference between the control group and the patients group in terms of RNFL, GCL, and IPL (p < 0.05). A significant difference between SGAG and CG, FGAG (p < 0.05); between control group and FGAG (p < 0.05) were found in terms of choroidal thickness. Conclusion: These findings suggested the deterioration of the metabolic parameters due to the SGA use. Thinner choroidal layer thickness in the CG compared to the SGAG and control group was thought to be related to the patients using clozapine had a resistance to the treatment.
Keywords:Antipsychotics, Retinal Ganglion Cell, Choroid, Optical Coherence Tomography, Schizophrenia