Background: Studying abroad can bring many advantages like learning new skills acquiring a competitive edge and gaining new skills that a person can never learn in his home country. Along with all these advantages international students also face many challenges. This study is mainly focused on indicating the potential factors that affect the mental health of students, yet the least studied. It can lead to many problems like difficulty in academics, this can destroy the purpose of going abroad. This review summarizes the most recent information on the variables affecting the mental health of international students with the aim of increasing awareness and encouraging additional study in this understudied field. Methodology: To identify different factors affecting the mental health of students we conducted a systematic review of studies that we took from online search engines like Google Scholar, PubMed, and Science Direct. 10 studies were included that met the inclusion criteria. All the included studies are written in English and published after 2010. Results: Our analysis revealed that new learning techniques, language barriers, currency changes, homesickness, and cultural changes are the potential factors that lead to mental disorders among students studying abroad. All these problems can lead to mental issues like depression, anxiety, stress, fear, social isolation, poor academic performance, and even suicidal ideation. It is important to acknowledge that there may be some limitations associated with research. Findings are associated with reviewed studies that may vary in research approach and sample size. Future studies should aim to review additional factors and address the limitations.