The interaction of epigenetics, childhood trauma, and anxiety disorders is a fascinating area of scientific study with significant ramifications for clinical practice and mental health. This abstract captures the intricate interplay between these factors, emphasizing how early-life hardships leave persistent biochemical fingerprints on a person's genetic composition, perhaps influencing the emergence of anxiety disorders. Through epigenetic pathways, childhood trauma, which includes events like abuse, neglect, and persistent stress, might influence a person's sensitivity to anxiety. These processes, which control the expression of genes involved in stress response, neurotransmitter signaling, and emotional regulation, include DNA methylation, histone changes, and microRNA regulation. The disturbance of the hypothalamic-pituitary-adrenal (HPA) axis and neuroplasticity provide as more evidence of the effects of trauma-induced epigenetic modifications, which manifest as altered brain circuits and stress response mechanisms. This complex interaction highlights how nature and nurture interact dynamically, enhancing our knowledge of the many-faceted causes of anxiety disorders. A need for focused treatments and therapies that address the molecular causes of anxiety is made as a result of the recognition of the long-lasting impacts of childhood trauma, giving those who are afflicted hope for better mental health outcomes and resilience.