This research study determines the efficacy of antidepressant medication related to the treatment of major depressive also disorders. This research study depends upon data these data collected from different websites related to the variables. the descriptive statistic analysis the correlation coefficients, and the regression analysis, also explain the ANOVA test analysis between them. Treatment results may differ based on a patient's characteristics, such as the severity of their depression, any co-occurring disorders, and heredity. This research study is based on the primary research data analysis to determine whether the research study used SPSS software and generated informative results. The overall result found that there is the significant effects of the efficacy of antidepressant medication in the treatment of the major depressive disorder. In some circumstances, combination therapies, such as antidepressant medication and psychotherapy, may be helpful. To create individualized treatment regimens, constant collaboration with healthcare specialists is necessary. Our understanding of treating depression is still shaped by ongoing research and scientific discoveries.