Objective: To evaluate efficacy and safety of acupuncture or acupuncture combined with traditional Chinese medicine in treatment of peptic ulcer (PU). Methods: A computer search was performed on treatment of digestion by acupuncture or its combination with traditional Chinese medicine and other methods published in Wanfang Database, China Journal Network Full-text Database, Chongqing VIP Database, China Biomedical Literature Database, PubMed and Cochrane Library from January 2008 to December 2021. The literatures that met inclusion criteria were extracted and quality evaluated, and Rev Man statistical software was used to carry out Meta-analysis of included literature data. Results: ①A total of 25 literatures were included, all of them in Chinese, with a total of 2233 patients; ②The results of meta-analysis showed that acupuncture combined with traditional Chinese medicine and western medicine had better curative effect than west-medicine alone (P<0.000 01), higher pyloric Helicobacter clearance rate (P<0.000 01), less adverse reactions (P<0.000 01) and lower recurrence rate (P<0.05), and can improve quality of life of patients. And subgroup analysis results showed that acupuncture combined with traditional Chinese medicine and western medicine respectively had better curative effect than west-medicine. Conclusion: Acupuncture combined with traditional Chinese medicine and west-medicine is a better solution for clinical treatment of peptic ulcer disease than pure west-medicine. However, due to low quality level of included literature, this conclusion needs to be treated with caution, and more clinical research is still needed. Sample, multi-center, high-quality randomized controlled trials for further research and validation.