Objective:To investigate the clinical epidemiologic features of human metapneumovirus (hMPV) infection in children with acute respiratory tract infections, in order to provide a reference for clinical diagnosis and treatment as well as disease prevention and control. Methods: A total of 5060 cases of children hospitalized with acute respiratory tract infections at our hospital from September 2021 to August 2022 were selected as study subjects, we developed a clinical case observation form, collected cases based on the prescribed uniform criteria, demographic and clinical data of all children were collected, and then divided into hMPV and non-hMPV groups according to whether or not they were infected with hMPV, and the demographic data, clinical manifestations and relevant laboratory tests and imaging findings of all children were compared. Demographics, clinical manifestations, and pertinent laboratory tests and imaging findings were compared and analyzed.Results:The proportion of hMPV-infected children was 25% (1265/5060) of total children;the sex ratio was 88.5% and 11.5% in the hMPV-treated group and 60.5% and 39.5% in the non-hMPV-treated group, respectively (P<0.05); the age of the hMPV group was <6 months, 6 months-2 years, 2 years-6 years and >6 years, 49.1%, 32.2% and 17.2% respectively. , 32.2%, 17.2%, and 1.5% in the hMPV group and 56.2%, 33.7%, and 10.1% in the non-hMPV group for age <6 months, 6 months to 2 years, and 2 years to 6 years, respectively (P<0.05); 73.9%, 2.5%, 2.5%, and 2.5% in the hMPV group for underlying diseases of pneumonia, laryngotracheobronchitis, asthmatic bronchitis, fine bronchitis, and bronchial calculi, respectively 2.5%, 2.5%, 0%, 18.2% in the hMPV group and 52.3%, 2.6%, 0%, 2.6%, 45.1% in the non-hMPV group for pneumonia, laryngotracheobronchitis, asthmatic bronchitis,fine bronchitis,and broncholithiasis,respectively(P<0.05). the proportions of patients in the HMPV arm for fever, cough, wheeze, vomiting, decreased appetite, diarrhea, and past history were 69.8%, 92.7%, 17.7%, 22.9%, 55.2%, 11.5%, 21.8%, and 57.9%, 48.5%, 15.2%, 19.7%, 37.2%, 4.6%, 15.3% in the non-hMPV arm (P<0.05).Conclusion: hMPV infection was more concentrated in younger children younger than 6 months; children infected with hMPV were more likely to contract pneumonia; children infected with hMPV had clinical manifestations of fever,cough,wheeze,vomiting,decreasedappetite, diarrhea, and a history of previous infection; childreninfectedwithhMPVfrequentlyhadanabnormalblood count.