Aim: For confirming the impact of Chaigui Antipyretic Granules Combined with Oseltamivirphosphate on Serum Indexes in Children with acute upper respiratory infection (AURI). Methods: From May 2020 to May 2022, 70 cases children with acute upper respiratory tract infection admitted to our hospital were stochastically separated into control subgroup and an observation subgroup, there was 35 cases children in each subgroup. The control subgroup was handled with conventional intervention and oseltamivir phosphate, while the observation subgroup was handled with Gui-antifebrile granules on top of the control subgroup, and both were treated for 1 week. The inflammatory factor concentrations, immune concentrations and the length of time taken for clinical symptoms to disappear were contrasted between the two subgroups before and afterintervention. Results: After intervention, IL-6 and PCT concentrations were lower in the observation subgroup than in the control subgroup; IgA and IgM were memorably lower than in the control subgroup and IgG was notablely higher than in the control subgroup; High fever, sore throat, cough and nasal congestion disappeared in a shorter time than in the control subgroup. Conclusion: Chaigui antipyretic granule linked with Oseltamivir Phosphate can rapidly relieve the clinical symptoms, improve the immunity of children with acute upper respiratory tract infection and reduce the inflammatory response.