Objective: To investigate the healing potential of minimally invasive care for osteoporotic vertebral fractures and to evaluate depressed patients. Methods: From February 2020 through August 2021, one hundred patients with osteoporotic vertebral fracture who were hospitalised to our hospital were chosen to participate in this study. Both the study's control and research groups, composed of 50 persons each, were selected at random. Comparatively, the research group underwent minimally invasive spinal treatment, while the control group received standard care. Clinical effectiveness, spinal recovery, pain level, lumbar function, degree of depression and anxiety, and quality of life were evaluated and compared. Results: With respect to overall efficacy, the treatment group's 96.00% success rate was statistically and practically significant more than the control group's 78.00%. After treatment, the Cobb Angle was lower than it was before treatment, and the two groups' anterior edge height, middle height, and posterior edge height were all higher than they were before treatment. Edge heights in the anterior, middle, and posterior positions were all higher in the research group than in the control group, and the Cobb Angle was lower in the research group than in the control group (P<0.05). When comparing post-treatment VAS and ODI scores to those before treatment, both groups showed improvement; however, the research group showed a greater improvement than the control group (P<0.05). After treatment, both groups' SDS and SAS scores were higher than their pre-treatment levels, however the improvements in the research group were statistically significant (P<0.05) compared to the control group. Both the research and control groups had an increase in quality of life after receiving the therapy, but the improvement in the research group was statistically significant (P<0.05) across all measures of physical function, psychological function, social function, and material lifestatus. Conclusion: The therapeutic effect of minimally invasive spinal surgery for osteoporotic vertebral fractures is substantial, making it worthwhile to spread awareness of and seek out for use in the treatment of these conditions.